It is roughly defined as bounded by Bloor Street to the south, Lawrence Avenue to the north, Oakwood Avenue to the west and Bayview Avenue to the east.
The intersection of Yonge and Eglinton is the heart of Midtown.
This place isn't an area with a large number of museums, theatres, or other tourist attractions.
The best way to enjoy it is to pretend that you live there, and enjoy the shops, restaurants, and cafes.
There are a lot of restaurant choices in Midtown, ranging from some of Toronto's best (and priciest) restaurants to neighbourhood establishments. Midtown also has some of the best pastry shops in the city.
To say that there are very few accommodation options in the area would be an understatement.
It's better to choose a downtown hotel and travel to midtown.